Status:
NOT_YET_RECRUITING
Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation
Lead Sponsor:
First Affiliated Hospital of Zhejiang University
Conditions:
Treatment Resistant Depression (TRD)
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
To compare the efficacy and safety of 6 times a day, 10 times a day acceleration mode and sham stimulation intervention for TRD, and to explore the antidepressant mechanism of accelerated mode, so as ...
Eligibility Criteria
Inclusion
- The current episode met the DSM-5 diagnostic criteria for major depression, without psychotic symptoms of the first or recurrent drug-free depressive subjects
- After a full course of treatment with two or more antidepressants, the patient had no response, and the level of treatment resistance was moderate to severe as assessed by the Maudsley staging method
- 24-item Hamilton depression Scale score ≥20
- The age ranged from 18 to 45 years, both sexes
- Right handed
- Written informed consent was obtained and patients volunteered to participate in the study and be evaluated.
Exclusion
- 1\. Comorbidity with other mental disorders, including schizophrenia, mental retardation, substance dependence, etc.
- 2\. Suffering from serious or unstable physical diseases
- 3, pregnant, lactating women, women of childbearing age screening period urine HCG test results are positive
- 4\. Subjects with metal objects in the body or other contraindications to MRI scanning
- 5\. There are other conditions considered by the investigator to be inappropriate for participation in the clinical trial.
Key Trial Info
Start Date :
March 25 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06881030
Start Date
March 25 2025
End Date
December 31 2025
Last Update
March 18 2025
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