Status:
ACTIVE_NOT_RECRUITING
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit
Lead Sponsor:
Pomeranian Medical University Szczecin
Collaborating Sponsors:
National Science Centre, Poland
Conditions:
Subarachnoid Hemorrhage, Aneurysmal
Delayed Cerebral Ischemia
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to investigate DNA methylation changes in adults with bleeding from brain aneurysm, which is called aneurysmal subarachnoid hemorrhage (aSAH), and their associa...
Detailed Description
This is a prospective observational case-control epigenome-wide association study (EWAS) designed to investigate DNA methylation changes in peripheral blood of patients with aneurysmal subarachnoid he...
Eligibility Criteria
Inclusion
- subarachnoid hemorrhage in computed tomography (CT) scan
- ruptured aneurysm identified with angio-CT or digital subtraction angiography (DSA)
- aneurysm successfully embolized or clipped
- obtained informed consent
- Hunt-Hess grade ≤ 3 by day 14 (initial higher grade was allowed providing that patient improved to grade 3 or higher by day 14)
Exclusion
- \< 18 years old
- unable to sign informed consent
- diagnosis of idiopathic perimesencephalic subarachnoid hemorrhage
- aneurysm identified more than 14 days after the ictus
- more than 14 days at the Intensive Care Unit
- remaining in Hunt Hess grade 5 or World Federation of Neurological Surgeons (WFNS) grade 5 from admission up to post-bleeding day 14
Key Trial Info
Start Date :
December 20 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT06881329
Start Date
December 20 2021
End Date
December 31 2025
Last Update
July 31 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Pomeranian Medical University Hospital No. 1
Szczecin, West Pomeranian Voivodeship, Poland, 71-252