Status:
RECRUITING
FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom
Lead Sponsor:
University College, London
Conditions:
Fuchs Dystrophy
Fuchs' Endothelial Dystrophy
Eligibility:
All Genders
18+ years
Brief Summary
FECD-TRACE is an integral component of a large research program dedicated to Fuchs Endothelial Corneal Dystrophy (FECD) in the United Kingdom. This longitudinal, observational study aims to comprehens...
Detailed Description
FECD is the most prevalent repeat expansion disease in humans. Clinical anticipation and intergenerational expansion of disease-associated repeats are features of other repeat expansion diseases, but ...
Eligibility Criteria
Inclusion
- Willing and able to provide informed consent for participation in the study
- Willing to attend scheduled study visits and undergo a clinical examination
- Willing to donate blood/saliva samples
- Fulfil the abovementioned cohort criteria
Exclusion
- Presence of a secondary cause for corneal endothelial dysfunction or oedema
- Presence of clinically evident corneal oedema
- History of concurrent corneal diseases
- History of corneal surgeries, including corneal transplantation
- Cognitive impairment or inability to provide informed consent for participation in the study
Key Trial Info
Start Date :
February 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06881771
Start Date
February 1 2024
End Date
February 1 2027
Last Update
March 18 2025
Active Locations (1)
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1
University College London
London, United Kingdom, EC1V 9EL