Status:
NOT_YET_RECRUITING
Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
Lead Sponsor:
University of Nebraska
Conditions:
Congenital Heart Disease (CHD)
Eligibility:
All Genders
1-3 years
Phase:
PHASE1
PHASE2
Brief Summary
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown...
Detailed Description
The goal of this study is to supplement a liquid form of butyric acid once daily for 3 weeks prior to cardiac surgery for infants and children, ages 1 month to 3 years, with congenital heart disease t...
Eligibility Criteria
Inclusion
- Infants and Children undergoing cardiac surgery with cardiopulmonary bypass
Exclusion
- Antibiotics, surgery, or chemotherapy within the past 8 weeks
- Continuous enteral feeds before surgery
- GI pathology or intestinal surgery (excluding G-tube)
- Liver disease with elevated transaminitis or dialysis-dependent renal disease
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT06882772
Start Date
June 1 2025
End Date
December 1 2028
Last Update
March 19 2025
Active Locations (1)
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1
Children's Nebraska, 8200 Dodge St
Omaha, Nebraska, United States, 68114