Status:

ENROLLING_BY_INVITATION

Clinical Relevance of Pathologic Regression IN Lymph Node for Locally Advanced Rectal Cancer

Lead Sponsor:

Yanhong Deng

Conditions:

Rectal Cancer

Lymph Node Metastasis

Eligibility:

All Genders

18-65 years

Brief Summary

We evaluated all related clinical and pathologic data of patients with Locally Advanced Rectal Cancer following Neoadjuvant Chemoradiotherapy, including the pathologic regression grading in the primar...

Detailed Description

This large-scale, multi-center cohort study investigates the clinical significance of Pathologic Regression in lymph nodes (LNs) of patients with Locally Advanced Rectal Cancer (LARC) following Neoadj...

Eligibility Criteria

Inclusion

  • \- Adults (≥18 years) diagnosed with locally advanced rectal adenocarcinoma (clinical stage II-III).
  • Completion of NCRT followed by curative-intent surgery. Availability of pre- and post-treatment histopathologic data, including standardized regression grading and digitized whole-slide images (WSIs).

Exclusion

  • \- distant Metastatic disease at diagnosis. Incomplete clinical or pathologic records.

Key Trial Info

Start Date :

January 30 2014

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

February 25 2026

Estimated Enrollment :

1080 Patients enrolled

Trial Details

Trial ID

NCT06883084

Start Date

January 30 2014

End Date

February 25 2026

Last Update

March 19 2025

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