Status:
COMPLETED
The Effects of Tyrosol and Creatine on Endurance, Strength, and Fatigue Resistance in Healthy Adults
Lead Sponsor:
Applied Science & Performance Institute
Conditions:
Tyrosol
Creatine
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this clinical trial is to look at tyrosol's effects on endurance, strength, and fatigue resistance in humans. Additionally, the combination of tyrosol and creatine monohydrate will also...
Detailed Description
This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 4-week intervention investigating the effects of tyrosol (500mg Tyrosol); placebo control (3g resis...
Eligibility Criteria
Inclusion
- Healthy males or females aged 18-50
- Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
- Estimated VO2 max equal to or greater than the 50th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
- Able to read and write in English
- During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
- Females willing to share days menstrual cycle for testing purposes as shifts in hormone levels may, potentially, affect testing
Exclusion
- Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
- Recent musculoskeletal injury (\<3-months)
- Recent orthopaedic surgery (\<12-months)
- History or current malignancy
- Previous gastrointestinal surgery within the past 12 months
- Regular smoker
- Regular drinker (\>14 drinks per week)
- Current use (within the past 4 weeks) of creatine supplements
- Current use (within past 3 months) of Tyrosol supplementation
- Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).
- Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)
- Female subjects who do not test negative on a urine pregnancy test or are lactating.
Key Trial Info
Start Date :
March 24 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06883292
Start Date
March 24 2025
End Date
August 30 2025
Last Update
September 11 2025
Active Locations (1)
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1
Applied Science & Performance Institute
Tampa, Florida, United States, 33634