Status:
RECRUITING
Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners
Lead Sponsor:
Mario Negri Institute for Pharmacological Research
Conditions:
Multiparametric MRI
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This is an interventional, multicenter, prospective study involving healthy volunteers, to primarily assess the reproducibility of multiparametric renal MRI on 1.5T scanners. The study is also aimed a...
Detailed Description
Over the past decade, renal Magnetic Resonance Imaging (MRI) has emerged as a promising non-invasive technique for improved understanding and characterisation of renal pathophysiology. Despite renal ...
Eligibility Criteria
Inclusion
- Provision of written informed consent prior to any study specific procedures
- Male and female subjects aged \[18-70\] years
- Office SBP values \< 140 mmHg and DBP values ≤ 90 mmHg, under no antihypertensive therapy
- Normal renal function defined as: estimated glomerular filtration rate \[eGFR\] ≥ 60mL/min/1.73m2 (using CKD-EPI Creatinine Equation)
- Negative result upon urine testing for haematuria or proteinuria.
Exclusion
- Previous enrollment in the present substudy
- Contraindications to MRI including caustrophobia, pregnancy, cardiac pacemakers or other MRI-incompatible prostheses
- Ongoing therapy (e.g. for diabetes, dyslipidemia, or any acute disease)
- Past or current oncological pathology
Key Trial Info
Start Date :
April 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06884410
Start Date
April 12 2025
End Date
April 1 2026
Last Update
September 2 2025
Active Locations (4)
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1
Aarhus University Hospital
Aarhus, Denmark, 8200
2
University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
Mannheim, Germany, 68197
3
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, BO, Italy, 40138
4
Clínica Universidad de Navarra
Pamplona, Navarre, Spain, 31008