Status:
RECRUITING
Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
Lead Sponsor:
CHU de Quebec-Universite Laval
Collaborating Sponsors:
Canadian Perioperative Anesthesia Clinical Trials (PACT) Group
Canadian Institutes of Health Research (CIHR)
Conditions:
Anesthesia
Anesthesia Complication
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedet...
Eligibility Criteria
Inclusion
- Adults \>/= 18 years.
- Having elective major non-cardiac surgery (i.e., planned duration \>/= 1.5 hours and anticipated \>/= 1 night hospital stay).
- Requiring general anesthesia.
- Able to complete baseline quality of recovery assessment.
Exclusion
- Individuals with known contraindications to dexmedetomidine or lidocaine (e.g., allergy to alpha-2 agonists or local anesthetics, severe renal or hepatic failure, bradycardia or hypotension), as per routine assessment.
- Regular use of alpha-2 agonists or local anesthetics prior to hospitalization.
- Pregnant women.
- Planned use of regional analgesia (i.e., epidural, peripheral nerve block, trunk nerve block) in conjunction with general anesthesia. Local anesthetics such as lidocaine are administered as part of regional analgesia technique. Combination with intravenous lidocaine is contraindicated to avoid exceeding therapeutic concentration.
- Planned postoperative intubation after PACU discharge.
- No fixed address.
Key Trial Info
Start Date :
July 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06884540
Start Date
July 15 2025
End Date
October 1 2027
Last Update
July 29 2025
Active Locations (1)
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1
CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus)
Québec, Quebec, Canada, G1J 1Z4