Status:
RECRUITING
Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS
Lead Sponsor:
Attikon Hospital
Conditions:
PCOS
Hyperinsulinism
Eligibility:
FEMALE
18-45 years
Brief Summary
The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers duri...
Detailed Description
All the woman who will recruited in the study will undergo OGTT. At 0, 60, and 120 min of glucose load the investigators will measure: a) glucose and insulin, b) pulse wave velocity (PWV) c) augmentat...
Eligibility Criteria
Inclusion
- Age \> 16 years old
- Diagonis of PCOS according to Rotterdam criteria: presence of two of the three of the following:
- Clinical or biochemical hyperandrogenism
- Anovulation or oligo-ovulation
- Polycystic ovarian morphology (PCOM)
- Absence of treatment for PCOS the last six months
- Patients who have the ability to understand and sign the consent form.
Exclusion
- Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone \[17-OHP\]), Cushing syndrome, acromegaly
- Treatment with contraceptive or metformin
- Type 2 diabetes mellitus
- Treatment for diabetes
- Pregnancy
- Lactation
- Malignancy
Key Trial Info
Start Date :
February 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06889454
Start Date
February 1 2024
End Date
February 1 2026
Last Update
November 19 2025
Active Locations (1)
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1
Attikon University General Hospital
Chaïdári, Greece, 124 62