Status:
RECRUITING
Circadian Rhythms in Human Adipose
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity, Abdominal
Feeding Patterns
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesi...
Detailed Description
This proposal will address 3 main aims: 1) Determine the impact of endogenous AT circadian rhythms on AT function independent of diurnal nutrient delivery in humans, 2) determine the impact of central...
Eligibility Criteria
Inclusion
- BMI 20-25 kg/m2 or 30-37 kg/m2
- For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
- sedentary
- females: non pregnant or breastfeeding
- ability to provide written informed consent and follow study instructions
Exclusion
- History of mediations that impact adipocyte/lipid metabolism
- smoking
- insomnia
- sleep apnea
- sleep medication use
- employment in night or shift work
- extreme chronotypes
- Allergy to lidocaine
Key Trial Info
Start Date :
July 7 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06891534
Start Date
July 7 2021
End Date
December 1 2030
Last Update
March 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Mayo Clinic
Rochester, Minnesota, United States, 55901