Status:
RECRUITING
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Lead Sponsor:
Apreo Health, Inc.
Conditions:
COPD
Emphysema
Eligibility:
All Genders
40-84 years
Phase:
NA
Brief Summary
The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphys...
Detailed Description
Prospective, randomized, two arm, parallel group, concurrently controlled, open-label, multi-center clinical trial following up to 250 participants to 3 years. Each site will participate in a Roll-In...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Subject is at least 40, but not older than 84, years of age.
- Subject has body mass index (BMI) of between 18 and 32, inclusive.
- Subject has completed a documented pulmonary rehabilitation program within 12 months prior to Baseline.
- Subject has mMRC score ≥ 2.
- Subject can walk ≥100 meters in 6 minutes.
- Subject has ≥25% emphysema destruction score in each lung as quantified on baseline HRCT scan (low attenuation area less than -950HU) as determined by the CT core lab.
- Subject has homogeneous or heterogeneous emphysema, and at least one lung has a 15% difference between upper and lower lobes in emphysema destruction score (-910HU) as determined by the CT core lab.
- Subject has bilateral heterogenous emphysema and pre-procedure post-bronchodilator RV ≥ 180% predicted, or one lung with homogenous emphysema and pre-procedure postbronchodilator RV ≥ 200% predicted.
- Subject has pre-procedure post-bronchodilator FEV1/ FVC \< 0.70.
- Subject has a pre-procedure post-bronchodilator FEV1 percent predicted of ≥15% and ≤45%.
- Subject has pre-procedure post-bronchodilator RV/TLC ≥ 0.55.
- Subject has pre-procedure DLCO ≥ 20%.
- Subject has been receiving optimal medical management tailored to subject needs for 2 months prior to enrollment.
- Subject has not actively smoked (including tobacco, marijuana, e-cigarettes, vaping, etc.) within the last 4 months, and agrees to smoking cessation during the study.
- Subject has received preventative vaccinations (or documented clinical intolerance) against potential respiratory infections, including pneumococcus, influenza, RSV (subjects \>60 yrs. old) and Covid-19, consistent with local recommendations or policy.
- In the opinion of the Primary investigator, subject can undergo bronchoscopy under general anesthesia and is able to adhere to the study follow-up schedule.
- Subject has provided written informed consent.
- Exclusion Criteria
- Subject has known unresolved lower respiratory tract infection (e.g., pneumonia, mycobacterium avium-intracellulare infection (MAI), fungus, tuberculosis).
- Subject has a steroid-dependent condition requiring (e.g. ≥10 mg oral corticosteroid per day).
- Subject has bilateral lobar emphysematous destruction scores of \>70% percent of voxels with \<-950 Hounsfield units on thin slice inspiratory CT, as determined by the CT core lab.
- Subject has arterial or capillary blood on room air: PaCO2 \> 50 mmHg (8 kPa) or PaO2 ≤ 45 mmHg (6 kPa).
- Subject has had ≥2 hospitalization for acute exacerbations of COPD or ≥3 moderate exacerbations/respiratory infections in the year prior to enrollment.
- Subject has had previous lung volume reduction surgery, lobectomy, pneumonectomy, segmentectomy, bullectomy, lung transplantation, vapor, glue, or other pulmonary device implant (unless the device has been removed at least 3 months prior to consent).
- Subject has known or suspected history of pulmonary arterial hypertension (e.g. PASP \> 50mmHg on echocardiogram in absence of confirmation on a right heart catheterization or mPAP \> 25mmHg on a right heart catheterization).
- Subject has presence of a giant bulla (≥ 30% of hemithorax).
- Subject has significant symptom burden due to currently active adult asthma based on GINA criteria and/or chronic bronchitis as their primary diagnosis.
- Subject has presence of suspicious radiological abnormalities on HRCT scan such as pulmonary nodule/infiltrate that in judgement of the PI, may require intervention during course of the study.
- Subject has clinically significant bronchiectasis (\>4 TBS / 45mL mucus production/day, per subject estimate) influencing subject's COPD symptoms.
- Subject has unresolved lung cancer.
- Subject has a serious medical condition that, in the Primary investigator's opinion, could compromise patient safety or confound the interpretation of the patient's response to therapy (e.g., congestive heart failure, cardiomyopathy (documented LVEF ≤40%), or myocardial infarction in the past year, renal failure, liver disease cerebrovascular accident within the past 6 months, uncontrolled diabetes (HbA1c \>8%), uncontrolled hypertension (diastolic BP \>110 mmHg or systolic \>200 mmHg) or autoimmune disease requiring treatment with immunosuppressant medications or a disease requiring chemotherapy.
- Subject is on anticoagulant or antiplatelet therapy for cardiovascular indications and, at the discretion of the Primary investigator, is unable to have anticoagulants withheld for a bronchoscopy procedure per institution's standard of care.
- Subject has invasive mechanical ventilator dependency.
- Subject is pregnant, lactating, or of childbearing potential and plans to become pregnant during study duration.
- Subject has known hypersensitivity to Nitinol (nickel-titanium alloy) or its constituent metals (nickel or titanium).
- Subject is significantly immunocompromised, such as organ transplant recipients, those with congenital immune deficiencies, AIDS, or severe rheumatoid arthritis.
- Subject has sensitivity or allergy to medications necessary for bronchoscopy under general anesthesia.
- Subject is currently participating in another study involving an investigational product that could confound the study results or affect the subject's COPD symptoms.
- Subject has within the 2 years prior to consent, had a severe respiratory infection with SARS-CoV-2 (COVID-19) that required ICU support with non-invasive and/or invasive mechanical ventilation.
Exclusion
Key Trial Info
Start Date :
July 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2029
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06891755
Start Date
July 15 2025
End Date
December 31 2029
Last Update
December 23 2025
Active Locations (18)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
2
Banner Health
Gilbert, Arizona, United States, 85234
3
University of California at Davis
Sacramento, California, United States, 95817
4
Mayo Clinic
Jacksonville, Florida, United States, 32224