Status:
ACTIVE_NOT_RECRUITING
Impact of Periodontal Therapy on AF Recurrence Post-Ablation in High-Inflammatory Burden Patients
Lead Sponsor:
Xu Liu
Collaborating Sponsors:
The First People's Hospital of Hefei City
The Second People's Hospital of Anhui Province
Conditions:
Atrial Fibrillation
Periodontitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Comparison of Non-Surgical Periodontal Therapy versus Background Periodontal Care in Reducing Atrial Fibrillation Recurrence in Patients with AF and Periodontitis: A Randomized Trial with Two Arms (Ba...
Eligibility Criteria
Inclusion
- \- Age ≥18 years. Diagnosed with atrial fibrillation (AF) and undergoing first-time catheter ablation.
- Diagnosed with periodontitis (2017 World Workshop classification) and periodontal inflamed surface area (PISA) \>500 mm².
- Willing and able to provide written informed consent.
Exclusion
- \- Requiring periodontal surgical intervention, e.g., flap surgery, bone grafting. Non-surgical periodontal therapy (e.g., scaling and root planing) within the past 6 months.
- Active systemic infection, e.g., sepsis, tuberculosis. Current immunosuppressive therapy, e.g., post-transplant medications, long-term corticosteroids.
- Chronic hepatitis B or HIV infection. Chronic systemic antibiotic use (\>4 weeks). Pregnancy or lactation. Anticipated survival \<12 months.
Key Trial Info
Start Date :
March 5 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT06892808
Start Date
March 5 2025
End Date
August 1 2026
Last Update
March 25 2025
Active Locations (1)
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1
Shanghai Chest Hospital
Shanghai, Xuhui, China, 200030