Status:
NOT_YET_RECRUITING
Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Preeclampsia
Pregnancy Loss
Eligibility:
FEMALE
18+ years
Brief Summary
Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization to evaluate the pharmacological effect in terms of placentation, gene e...
Detailed Description
Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization. Placental organoid model can be used in the study of placental pathoph...
Eligibility Criteria
Inclusion
- Women with uncomplicated normal term pregnancy undergoing elective cesarean section for previous uterine surgery or breech presentation of the fetus;
- Patients with retained abortion and history of recurrent abortion sine causa at the end of the work-up of investigations performed according to ESHRE guidelines, undergoing revision of the uterine cavity;
- Patients diagnosed with preeclampsia, defined in accordance with the definitions of ISSHP, undergoing cesarean section;
- Patients with preterm onset, before 37 weeks gestational age, of spontaneous labor, undergoing cesarean section in labor for low weight or abnormal fetal presentation.
Exclusion
- Age \<18 years;
- Chronic infection with HIV or HCV;
- Ongoing malignant neoplasms;
- Multiple pregnancies;
- Inability to provide informed informed consent.
Key Trial Info
Start Date :
May 20 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06893978
Start Date
May 20 2025
End Date
November 1 2027
Last Update
May 20 2025
Active Locations (1)
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1
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Ostetricia e Patologia Ostetrica
Rome, Lazio, Italy, 00168