Status:
RECRUITING
Impact of IIT-SIT on Dengue Clusters
Lead Sponsor:
National Environment Agency, Singapore
Collaborating Sponsors:
Ministry of Health, Singapore
Conditions:
Dengue
Eligibility:
All Genders
Phase:
NA
Brief Summary
This randomized controlled trial aims to evaluate the efficacy of Wolbachia-infected male mosquitoes combined with sterile insect technique (IIT-SIT) to mitigate active dengue transmission in Singapor...
Detailed Description
Aedes-borne diseases are expected to increase in geographical coverage and intensity due to climate change and rapid urbanization. It has been demonstrated that Wolbachia-mediated incompatible insect ...
Eligibility Criteria
Inclusion
- Eligible dengue clusters will be limited to public housing estates and with at least 10 dengue cases comprising that dengue cluster before allocation into intervention or control arms. The selected clusters will be in areas with relatively high sector-level GAI of at least 0.2 at the time of the 10th reported case. Additionally, the first 10 cases must be reported within 30 days of the first case. Additionally, clusters must be in areas which have never experienced Wolbachia-Aedes releases and at least 700 m away from existing Wolbachia-Aedes release areas.
Exclusion
Key Trial Info
Start Date :
March 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 20 2028
Estimated Enrollment :
900 Patients enrolled
Trial Details
Trial ID
NCT06894901
Start Date
March 20 2025
End Date
January 20 2028
Last Update
March 25 2025
Active Locations (1)
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1
National Environment Agency
Singapore, Singapore