Status:
RECRUITING
Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
Lead Sponsor:
Beijing Tsinghua Chang Gung Hospital
Conditions:
Myocardial Injury After Non-Cardiac Surgery
Ischemia Reperfusion Injury
Eligibility:
All Genders
45-85 years
Brief Summary
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mech...
Detailed Description
This observational cohort study consists of both retrospective and prospective components. The study population includes patients undergoing major hepato-biliary surgery (defined as operative time \> ...
Eligibility Criteria
Inclusion
- Age ≥ 65 years, or ≥ 45 years with cardiovascular risk factors (especially known cardiovascular disease).
- Undergoing elective major hepatopancreatobiliary surgery under general anesthesia.
- ASA physical status II-III.
- Provide written informed consent to participate in the study (applicable to the prospective cohort).
Exclusion
- Emergency surgery
- Preoperative diagnosis of myocardial infarction or unstable angina
- Severe hepatic insufficiency (Child-Pugh class C)
- Concomitant severe organ dysfunction (e.g., renal failure, respiratory failure)
- Concomitant active infectious disease
Key Trial Info
Start Date :
January 4 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT06895798
Start Date
January 4 2023
End Date
April 1 2026
Last Update
May 15 2025
Active Locations (1)
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1
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University
Beijing, Beijing Municipality, China, 102218