Status:
NOT_YET_RECRUITING
Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?
Lead Sponsor:
Esbjerg Hospital - University Hospital of Southern Denmark
Conditions:
Postbariatric Hypoglycemia
Eligibility:
All Genders
Brief Summary
The goal of this observational study is to learn about how bariatric surgery affects the metabolism of cortisol. The main question it aims to answer is whether changes in cortisol contribute to the d...
Detailed Description
Purpose The project investigates how bariatric surgery affects the metabolism of cortisol. Additionally, it examines whether changes in cortisol contribute to the development of reactive hypoglycemia,...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Participants must have undergone one of the following bariatric procedures at least 12 months prior:
- Roux-en-Y gastric bypass
- Gastric sleeve
- Exclusion Criteria
- Pregnancy and breastfeeding
- Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration
- Use of corticosteroid medications, such as prednisolone
- Use of opiod-containing medication
- Use of medications containing estrogen, such as hormone therapy for menopause
- Known adrenal disease affecting cortisol metabolism, including autonomous cortisol production and Cushing's syndrome
- Diabetes that does not require medical treatment
- Previously diagnosed reactive hypoglycemia after bariatric surgery requiring medical treatment
Exclusion
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06896682
Start Date
May 1 2025
End Date
December 31 2026
Last Update
April 18 2025
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