Status:
ACTIVE_NOT_RECRUITING
Regeneration of Knee and Ankle Cartilage From Autologous Cartilage Mini-grafts (From the Patient's Own Cells)
Lead Sponsor:
Vanarix SA
Conditions:
Cartilage Repair
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to investigate the safety and feasibility of implanting autologous cartilage mini-grafts (or Cartibeads) into cartilage defects in the knee and ankle. Cartibeads are engi...
Eligibility Criteria
Inclusion
- Key inclusion criteria:
- Cartilage focal lesion(s) ≥ 1.5 cm2 and ≤ 10 cm2
- ICRS grade 3 or 4
- Pain for 3 months or more
- Aged over 18 years
- Key exclusion criteria
- Inability to undergo MRI
- Cartilage specific surgery within 12 months from baseline
- Cartilage therapeutic injection within 3 months from baseline
- Radiologically apparent degenerative joint disease (K\&L grade \>1)
- Chronic inflammatory arthritis and/or infectious arthritis
Exclusion
Key Trial Info
Start Date :
June 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 2 2025
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT06897098
Start Date
June 10 2022
End Date
April 2 2025
Last Update
March 26 2025
Active Locations (3)
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1
Center for Sports Medicine and Exercise, Hirslanden Clinique La Colline
Geneva, Canton of Geneva, Switzerland, 1206
2
Geneva University Hospitals (HUG)
Geneva, Canton of Geneva, Switzerland, 1211
3
Ente Ospedaliero Cantonale (EOC)
Lugano, Canton Ticino, Switzerland, 6962