Status:
ACTIVE_NOT_RECRUITING
Intracardiac Echocardiography-Guided Catheter Ablation for Premature Ventricular Contractions Originating From the Papillary Muscles
Lead Sponsor:
Shanghai Chest Hospital
Collaborating Sponsors:
The Second People's Hospital of Anhui Province
The First People's Hospital of Hefei
Conditions:
Premature Ventricular Contractions
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized, prospective, parallel, single-blind, multicenter clinical trial investigates the efficacy and safety of intracardiac echocardiography (ICE)-guided catheter ablation versus pressure-se...
Eligibility Criteria
Inclusion
- Patients aged ≥18 years.
- Diagnosed with premature ventricular contractions (PVCs) originating from the papillary muscles.
- Symptoms refractory to antiarrhythmic drug therapy.
- Patients must be capable and willing to provide written informed consent for study participation.
Exclusion
- History of cardiac surgery or any prior cardiac interventional procedures.
- Ischemic heart disease, dilated cardiomyopathy, or hypertrophic cardiomyopathy.
- Severe hepatic or renal dysfunction:
- AST/ALT \>3× upper limit of normal (ULN); Serum creatinine (SCr) \>3.5 mg/dl or creatinine clearance (Ccr) \<30 ml/min.
- Prior ablation for papillary muscle PVCs.
- Life expectancy \<1 year.
- Pregnancy or lactation.
Key Trial Info
Start Date :
March 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
156 Patients enrolled
Trial Details
Trial ID
NCT06898281
Start Date
March 23 2025
End Date
March 1 2026
Last Update
April 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Shanghai Chest Hospital
Shanghai, Xuhui, China, 200030