Status:
RECRUITING
Attention and Eye Movement in Parkinson's Disease
Lead Sponsor:
University of Nebraska
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Essential Tremor
Parkinson's Disease (PD)
Eligibility:
All Genders
19-90 years
Phase:
NA
Brief Summary
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disea...
Detailed Description
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder, with approximately 90,000 new cases diagnosed annually in North America. Although motor symptoms define the d...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- All Participants (Aim 1):
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- DBS Participants (Aim 1):
- Diagnosis of idiopathic Parkinson's disease (PD) or essential tremor (ET)
- Scheduled for new implantation of a therapeutic DBS device targeted to subthalamic nucleus (STN), ventral intermediate nucleus of thalamus (VIM) or internal globus pallidus (GPi)
- Comparison Participants (Aim 1):
- o Selection by age matching to participants in PD group
- Parkinson's disease (PD) and essential tremor (ET) Participants (Aim 2):
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- Scheduled for awake DBS implantation with clinical micro-electrode recordings (MER)
- Willing and able to engage in tasks during an awake surgical procedure
- Parkinson's disease (PD) and essential tremor (ET) Participants (Aim 3):
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- Willing to undergo acute manipulations of DBS
- Able to tolerate acute changes of DBS
- Exclusion Criteria
- All Participants (Aim 1):
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- DBS Participants (Aim 1):
- o Insufficient therapeutic control of motor symptoms to engage in tasks requiring button press or use of a mouse to control a slider
- Healthy Comparison Participants (Aim 1):
- o History of neurodegenerative disorder
- Parkinson's disease (PD) and essential tremor (ET) Participants (Aim 2):
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- Not undergoing awake DBS implantation
- Uncorrected visual acuity insufficient to perceptually judge face stimuli
- Parkinson's disease (PD) and essential tremor (ET) Participants (Aim 3):
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- Failure of DBS to achieve a therapeutic effect on motor symptoms
Exclusion
Key Trial Info
Start Date :
September 22 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2028
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT06899022
Start Date
September 22 2025
End Date
August 1 2028
Last Update
December 23 2025
Active Locations (1)
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1
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198