Status:
WITHDRAWN
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
Shanghai Chest Hospital
Shanghai Xuhui Central Hospital
Conditions:
Postoperative Delirium (POD)
Postoperative Sleep Disturbance
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical ex...
Eligibility Criteria
Inclusion
- Age ≧ 65 years;
- ASA Ⅰ-Ⅲ;
- Elective major non-cardiac surgery;
- Voluntary signed informed consent.
Exclusion
- People with mental illness;
- Suffering from serious central nervous system disorders such as arkinson's disease, Alzheimer's disease, etc;
- Elevated intracranial pressure;
- Emergency or trauma surgery;
- Prior history of postoperative delirium or postoperative cognitive decline;
- The patient has impaired hearing or impaired vision;
- Suffering from severe systemic underlying diseases (e.g. cardiac insufficiency, malignant arrhythmia, malignant hypertension, hepatic failure, renal failure, etc.);
- The patient is in chronic pain;
- The patient is severely malnourished;
- Patients with stage 3 or 4 malignant tumors, pancreatic cancer, allbladder cancer, cholangiocarcinoma and other tumors with high malignancy and poor prognosis.
- history of allergy to or contraindication to esketamine;
- inability or unwillingness to complete questionnaires or clinical testing;
- Unable or unwilling to use a postoperative intravenous analgesic pump.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2026
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT06900205
Start Date
April 1 2025
End Date
September 30 2026
Last Update
May 16 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200127