Status:
WITHDRAWN
A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes
Lead Sponsor:
Eli Lilly and Company
Conditions:
Obesity
Overweight
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
The main purpose of this study is to see how well and how safely bimagrumab, tirzepatide, and the combination, work in lowering body weight in participants with obesity or overweight and type 2 diabet...
Eligibility Criteria
Inclusion
- Have type 2 diabetes
- Have a BMI of ≥27 kilograms per square meter (kg/m2)
- Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss)
Exclusion
- Have a prior or planned surgical treatment for obesity,
- Have type 1 diabetes, latent autoimmune diabetes, or history of ketoacidosis or hyperosmolar state or coma
- Have poorly controlled hypertension
- Have any of the following cardiovascular conditions within 3 months prior to screening:
- acute myocardial infarction
- cerebrovascular accident (stroke)
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history of New York Heart Association (NYHA) Functional Classification III or IV congestive heart failure
- Have ongoing or a history of frequent intermittent or chronic tachyarrhythmia syndromes
- Have ongoing or a history of bradyarrhythmias other than sinus bradycardia
- Have renal impairment
- Have a history of symptomatic gallbladder disease within the past 2 years
- Have signs and symptoms of any liver disease
- Have a disease or condition known to cause gastrointestinal malabsorption or a known clinically significant gastric emptying abnormality
- Have a history of acute or chronic pancreatitis
- Currently taking or have taken medications that may cause significant weight gain or promote weight loss within 3 months prior to screening
Key Trial Info
Start Date :
May 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 10 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT06901349
Start Date
May 23 2025
End Date
June 10 2025
Last Update
September 24 2025
Active Locations (50)
Enter a location and click search to find clinical trials sorted by distance.
1
Yuma Clinical Trials
Yuma, Arizona, United States, 85364
2
Orange County Research Center
Lake Forest, California, United States, 92630
3
Healthy Brain Clinic
Long Beach, California, United States, 90804
4
Valley Clinical Trials, Inc.
Northridge, California, United States, 91325