Status:
ACTIVE_NOT_RECRUITING
The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery
Lead Sponsor:
Nanjing First Hospital, Nanjing Medical University
Conditions:
Postoperative Delirium (POD)
Eligibility:
All Genders
60+ years
Brief Summary
Postoperative delirium after cardiac surgery is an acute cerebral dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances. It manifests clinically ...
Eligibility Criteria
Inclusion
- Undergoing elective cardiac surgery with cardiopulmonary bypass (such as coronary artery bypass grafting, bioprosthetic valve replacement, valve repair, congenital heart surgery, etc.);
- Age ≥ 60 years.
Exclusion
- Aortic dissection and other surgeries involving major blood vessels;
- A history of mental illness with related medication use; preoperative Mini-Mental State Examination (MMSE) score \< 27; preoperative delirium;
- A history of neurosurgery or traumatic brain injury; if a focal brain lesion larger than 3 cm occurs during the study, the data will be excluded from subsequent analyses;
- Hearing and language impairments that affect communication;
- Contraindications to MRI (e.g., presence of metal implants in the body, including prosthetic valve replacement, internal fixation plates after fracture surgery, etc.).
Key Trial Info
Start Date :
March 10 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06901479
Start Date
March 10 2025
End Date
December 31 2028
Last Update
March 30 2025
Active Locations (1)
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1
Nanjing First Hospital
Nanjing, Jiangsu, China, 210000