Status:
COMPLETED
Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients
Lead Sponsor:
Ain Shams University
Conditions:
Intra-Abdominal Infections
Intestinal Obstruction
Eligibility:
All Genders
18+ years
Brief Summary
In this study the investigators going to evaluate the "CLI" as an early prognostic indicator for post-operative abdominal sepsis in critically ill patients.
Detailed Description
Sepsis has been recognized as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Considerable advances have since been made into the pathobiology (changes in org...
Eligibility Criteria
Inclusion
- Age: ≥18 years old presented with Post-operative intra-abdominal sepsis due to secondary peritonitis.
- Sex: Both sexes.
- Post-Operative secondary peritonitis eg. Perforated viscus and abdominal abscess.
- Estimated length of ICU stays ≥48 hrs.
Exclusion
- Patient refusal.
- Advanced Liver diseases According New MELD score ≥ 20 )Kamath et al.,2001)
- Renal diseases (Moderate decrease in GFR 30-59 ml/min/1.73m²--Severe decrease in GFR 15-29 ml/min/1.73m²--Kidney failure less than 15 ml/min/1.73m² or on Hemodialysis).
- Pregnancy.
- Primary peritonitis.
- Tertiary peritonitis.
- Mortality within first 48hrs of ICU admission.
- Advanced malignancy ( Stage III localized malignancy with spreading lymph nodes Stage IV spreading to Other parts of the body such as to the liver, lungs and bones).
Key Trial Info
Start Date :
March 4 2025
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 10 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06901544
Start Date
March 4 2025
End Date
August 10 2025
Last Update
December 24 2025
Active Locations (1)
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1
Surgical intensive Care Unit, Ain Shams University Hospitals.
Cairo, Cairo Governorate, Egypt, 7154411