Status:
RECRUITING
Efficacy of Lactobacillus Rhamnosus LRa05 in Gestational Diabetes
Lead Sponsor:
Wecare Probiotics Co., Ltd.
Conditions:
GDM
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study aims to comprehensively evaluate the multifaceted impacts of Lactobacillus rhamnosus LRa05 on patients with gestational diabetes. Initially, the study will investigate the effects of LRa05 ...
Eligibility Criteria
Inclusion
- Women diagnosed with gestational diabetes mellitus (GDM) at 24 weeks of gestation.
- Diagnostic criteria for GDM: Abnormal oral glucose tolerance test (OGTT) with an 82.5g glucose load during the 24th week of pregnancy (defined as meeting one or more of the following plasma glucose thresholds: fasting ≥ 5.1 mmol/L, 1-hour ≥ 10 mmol/L, or 2-hour ≥ 8.5 mmol/L).
- Pregnant women aged 18 to 50 years.
- Singleton pregnancy with a fetus confirmed to be structurally and chromosomally normal via ultrasound or other prenatal diagnostic methods.
- No history of chronic diseases, including immune deficiency, hypertension, diabetes, kidney disease, or liver disease.
- No consumption of probiotic-containing foods (e.g., yogurt, fermented foods, soybean paste) within the two weeks prior to the study.
- Willing and able to provide written informed consent.
- Capable of complying with the study protocol and follow-up requirements.
Exclusion
- Those who have taken items with similar functions to the test product in the short term, which may affect the judgment of the results.
- Those with other endocrine diseases or currently using medications that affect blood glucose control.
- Those with severe cardiovascular, kidney, or liver diseases.
- Those with immunodeficiency diseases or currently using immunosuppressive agents.
- Those with severe gastrointestinal diseases that may affect the absorption or metabolism of probiotics.
- Those currently using other medications that may affect blood glucose control or lipid levels.
- Those with a history of allergy to probiotics or any components of the study products.
- Those with unhealthy lifestyle habits, such as smoking, alcohol consumption, or drug abuse.
- Those who do not consume the test samples as required or do not follow up on time, resulting in uncertain efficacy.
- Study participants deemed unsuitable by other researchers.
Key Trial Info
Start Date :
April 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 10 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06901791
Start Date
April 10 2025
End Date
March 10 2026
Last Update
March 30 2025
Active Locations (1)
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1
Suzhou Municipal Hospital
Suzhou, Jiangsu, China