Status:
RECRUITING
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Lead Sponsor:
Texas Tech University Health Sciences Center
Conditions:
Orthopedic Trauma Surgery Patients
Postoperative Pain
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, l...
Detailed Description
Orthopedic trauma patients often face challenges in both physical and psychological recovery following injury. Pain control is difficult, as effective pain relief must be balanced against the risks of...
Eligibility Criteria
Inclusion
- Adults aged 18-65
- Undergoing acute operative fixation for musculoskeletal trauma
- Injury Severity Score (ISS) greater than 15
- Ability to provide informed consent (or consent provided by a legally authorized representative)
Exclusion
- Age under 18 or over 65
- Use of ketamine for preoperative or postoperative sedation
- Known allergy or contraindication to ketamine
- Prior unsuccessful ketamine therapy for major depressive disorder (MDD) or PTSD
- Severe psychiatric conditions or psychotic features
- History of dementia or glaucoma
- Currently engaged in trauma-focused cognitive behavioral therapy or PTSD psychotherapy started within the past 3 months
Key Trial Info
Start Date :
November 6 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2028
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06903819
Start Date
November 6 2025
End Date
May 1 2028
Last Update
December 3 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Texas Tech University Health Sciences Center Lubbock
Lubbock, Texas, United States, 79415
2
University Medical Center
Lubbock, Texas, United States, 79415