Status:
NOT_YET_RECRUITING
Efficacy and Mechanisms of TUS on Cognitive Deficits in Schizophrenia: Based on the Hippocampal-Prefrontal Circuit
Lead Sponsor:
Shanghai Mental Health Center
Conditions:
Cognitive Deficit in Schizophrenia
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome. Prior studies indicated that abnormalities in the hippocampus-prefrontal circuit and glutamate/GABA imbalance...
Detailed Description
Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome which remains largely treatment refractory. Prior studies indicated that abnormalities in the hippocampus-pref...
Eligibility Criteria
Inclusion
- Meet the DSM-5 diagnostic criteria for schizophrenia ;
- Age18-50, right-handed, Han nationality;
- Presence of cognitive deficit: defined as d' value \<0.5 in associative memory test;
- Be in a stable condition, received second-generation antipsychotics for at least 4 weeks or more;
- Written informed consent;
Exclusion
- Current or past neurological illness, severe physical diseases, substance abuse or alcohol dependence, mental retardation, pregnancy or lactation;
- Uncooperative or risky patients with high excitement, stupor, disorder of words and deeds, negative suicide, etc.;
- History of MECT or other physical therapy within 6 months;
- History of epilepsy, or epileptic waves on the baseline EEG;
- Ruled out share antiepileptic drugs (carbamazepine, valproic acid salt) or larger doses of benzodiazepine drugs (diazepam \> 10mg/day, clonazepam \> 2mg/day etc.), if necessary, remain unchanged during the course of treatment;
- Contraindications to TUS and MRI are present.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT06904092
Start Date
April 1 2025
End Date
December 31 2027
Last Update
April 1 2025
Active Locations (1)
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1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030