Status:
RECRUITING
Using 4D Urinary Proteomics to Predict and Evaluate Treatment Response in Colorectal Cancer
Lead Sponsor:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conditions:
Colorectal Cancer (CRC)
Neoadjuvant Therapy
Eligibility:
All Genders
18-75 years
Brief Summary
The goal of this observational study is to learn how well urinary proteins can predict treatment response in patients with locally advanced colorectal cancer (LACC) undergoing neoadjuvant therapy. The...
Detailed Description
Neoadjuvant therapy is one of the main treatment strategies for patients with locally advanced colorectal cancer (LACC). However, the response to neoadjuvant therapy varies greatly among individuals, ...
Eligibility Criteria
Inclusion
- Aged 18-75 years;
- Pathologically confirmed diagnosis of locally advanced colorectal cancer (cT3-4 and/or N+);
- Planned to undergo neoadjuvant therapy followed by surgical resection;
- No evidence of distant metastasis (M0) confirmed by imaging (CT and/or PET-CT);
- Clinically assessed as being able to tolerate and complete the full course of neoadjuvant treatment;
- No prior anti-tumor therapy (e.g., targeted therapy, immunotherapy) before the initiation of treatment;
- Willing and able to provide urine samples as required;
- Written informed consent obtained.
Exclusion
- History of or concurrent diagnosis with other malignancies;
- Presence of severe hepatic, renal, cardiovascular, or metabolic diseases that may affect urinary protein metabolism;
- Recent use of medications known to affect protein metabolism (e.g., glucocorticoids, high-dose antibiotics);
- Urinary tract infection or other diseases known to cause abnormal urinary protein levels (e.g., nephrotic syndrome);
- Any other condition deemed unsuitable for enrollment by the investigators.
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2029
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06904677
Start Date
May 1 2025
End Date
May 1 2029
Last Update
November 28 2025
Active Locations (1)
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1
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Chaoyang District, China, 100021