Status:
NOT_YET_RECRUITING
The Use of Advanced Imaging in HFpEF
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Conditions:
Heart Failure With Preserved Ejection Fraction (HFPEF)
Eligibility:
All Genders
18+ years
Brief Summary
Heart failure with preserved ejection fraction (HFpEF) causes symptoms of breathlessness and leg swelling. It is associated with significant number of hospital admissions and could lead to the patient...
Detailed Description
The investigators will recruit patients from the Diagnostic heart failure (HF) clinic at Northern General Hospital, Sheffield. Patients with symptoms suggestive of HF but with an indeterminate diagnos...
Eligibility Criteria
Inclusion
- Male or female \> 18yrs of age.
- Symptoms of dysponea on exertion.
- NTproBNP \>400 ng/L in sinus rhythm (SR).
- Baseline TTE demonstrating a dilated LA (LA\>34 ml/m2), but that otherwise does not meet the current criteria for the diagnosis of HFpEF or HFrEF (preserved LV systolic function, Normal E/e', no evidence of LVH, Estimated PAP \< 35mmhg).
Exclusion
- Inability to give informed consent. History of HFrEF
- contraindications to SGLT2 inhibitor (a history of type 1 diabetes mellitus, ketoacidosis, allergy to SGLT2 inhibitors, planned or current use of SGLT2 inhibitors or active genital infection).
- Atrial Fibrillation.
- Current history of anginal chest pain
Key Trial Info
Start Date :
July 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06905405
Start Date
July 1 2025
End Date
September 30 2026
Last Update
May 30 2025
Active Locations (1)
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1
University of Sheffield
Sheffield, United Kingdom, S10 2TN