Status:
RECRUITING
The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders.
Lead Sponsor:
Qing Su
Conditions:
Immunosenescence
Metabolism
Eligibility:
All Genders
50-70 years
Phase:
NA
Brief Summary
The ageing of our country is increasing and the ageing of the population has led to a significant increase in aging related diseases. During the aging process of the organism, cellular senescence can ...
Detailed Description
A randomised, placebo-controlled, parallel group study to assess the efficacy and safety of NMN in middle-aged and elderly people with immunosenescence. People aged 50-70 years will be included in the...
Eligibility Criteria
Inclusion
- Age 50-70 years with overweight or obesity (BMI 24kg/m2);
- At least one of the following three: metabolism-related fatty liver disease (diagnosed by ultrasound); pre-diabetes; type 2 diabetes mellitus with HbA1c \<7% without glucose-lowering drug therapy;
- Agreed to participate in the trial and could adhere to the follow-up and visit the hospital on their own; signed the informed consent form.
Exclusion
- Patients with tumours;
- Patients with autoimmune diseases (excluding Hashimoto's thyroiditis);
- Severe cardiovascular disease or cardiac insufficiency;
- Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 100 mmHg;
- Chronic obstructive pulmonary disease;
- Chronic active hepatitis or cirrhosis;
- Chronic renal insufficiency;
- Stroke patients
- Severe haematological diseases;
- Infectious diseases;
- Mental illness;
- Other conditions that, in the opinion of the investigator, may affect the results of the study;
- Those who have used NMN or other anti-aging agents within six months.
- Premenopausal woman
- ALT, AST values are more than three times higher than the upper limit of the normal reference range
Key Trial Info
Start Date :
June 5 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT06907329
Start Date
June 5 2025
End Date
March 31 2027
Last Update
July 8 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China