Status:
RECRUITING
Yeast Mannans and Stool Frequency
Lead Sponsor:
University of Florida
Conditions:
Defecation Frequency
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and incre...
Eligibility Criteria
Inclusion
- Adults who report a stool frequency of ≤ 1 per day.
- Able to provide written informed consent in English.
- Willingness to consume 1 supplement (12 g of yeast mannans or control) daily for 28 days.
- Willingness to maintain their usual diet and physical activity patterns throughout the study and refrain from the consumption of any yeast-based foods (e.g. Marmite or Vegemite) or yeast extract supplements.
- Willing to comply with study procedures, including stool and urine colle
Exclusion
- Stool frequency of \< 3 per week
- Yeast allergy
- Vegan dietary pattern
- Self-reported kidney disease
- Elite athletes or long-distance runners
- Use of antibiotic drugs within 1 month of screening
- Current use of laxatives or antidiarrheal medications
- Use of other investigational products within 3 months of the screening
- Previously or currently being treated for intestinal diseases or conditions, including irritable bowel disease (i.e., IBS-D or IBS-mixed), Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal cancer.
- Previous gastrointestinal surgery (e.g., gastric bypass, fundoplication, bowel resection).
- Current cancer treatment.
- Currently pregnant.
Key Trial Info
Start Date :
July 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06911177
Start Date
July 17 2025
End Date
June 30 2026
Last Update
August 11 2025
Active Locations (1)
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1
Department of Food Science and Human Nutrition
Gainesville, Florida, United States, 32611