Status:
NOT_YET_RECRUITING
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
Lead Sponsor:
University of Alberta
Conditions:
Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroy...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Both male and female participants will be included
- History of Stroke Symptoms
- Baseline modified Rankin scale score \< 2
- Participant or substitute decision-maker able to provide informed consent.
Exclusion
- Injury to the upper arms, lower limbs (from ankles to thighs), or any other musculoskeletal disability/pain that precludes tolerating RIC and/or Pneumatic compression therapy.
- History of dermatological conditions affecting application of RIC cuff with tissue perfusion sensor and pneumatic compression boots.
- History of peripheral arterial disease
- Treatment of ongoing malignancy with expected survival \< 6 months
- Presence of hypertensive urgency and emergency
- Presence of hemodynamic instability and ongoing pulmonary edema
- Presence of clinical or imaging signs of raised intracranial, intrathoracic, and /or intra-abdominal pressure.
- Presence of ongoing systemic infection with antibiotic therapy
- Pregnant and lactating women
- Participant not part of other clinical intervention trial
Key Trial Info
Start Date :
February 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06911385
Start Date
February 1 2026
End Date
May 31 2027
Last Update
January 6 2026
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