Status:
NOT_YET_RECRUITING
Investigating How the RECT Impacts Brain Functional States Through the ACC-cerebellar Loop
Lead Sponsor:
The Second Affiliated Hospital of Kunming Medical University
Conditions:
Post-stroke Depression
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Experiment1: Using a brain EEG-TMS combined system, researchers aim to investigate the impact of the rostral anterior cingulate cortexr (rACC)-engaging cognitive task (RECT) combined single-pulse TMS ...
Eligibility Criteria
Inclusion
- Onset of stroke \<6 months ago, or \>6 months since the last stroke event;
- Age \>=18 years and \<85 years (as the probability of Vascular Cognitive Impairment increases above 85);
- Patients with damage in the middle cerebral artery territory;
- NIHSS \>4 and \<26;
- mRS score \>=2;
- Completion of CT or MRI;
- No neurological or psychiatric disorders; no impairment of consciousness; able to comply with relevant treatments; no severe cognitive dysfunction (MMSE \>=15);
- All participants are right-handed; Sign the informed consent form.
Exclusion
- History of epilepsy or psychiatric disorders (including depression, anxiety, or schizophrenia);
- Severe comorbidities;
- History of medication use: benzodiazepines, baclofen, antidepressants;
- Non-compliance with the treatment plan;
- Acute-phase cerebral hemorrhage, acute infectious diseases;
- Severe suicidal tendencies in individuals with depression;
- Individuals suffering from severe headaches, high blood pressure, malignant tumors, open wounds, vascular embolism, leukopenia, etc.;
- Severe alcohol abuse;
- History of cranial surgery, individuals with metal implants in the brain;
- Individuals with an implanted cardiac pacemaker;
- NIHSS \>26, MMSE \<15;
- Any disease likely to prevent the patient from surviving more than one month;
- Pregnant individuals.
Key Trial Info
Start Date :
March 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 30 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06912191
Start Date
March 30 2025
End Date
May 30 2027
Last Update
April 4 2025
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