Status:
RECRUITING
Continous Positive Airway Pressure (CPAP) Support for Acute Hypoxemic Respiratory Failure in Burkina Faso
Lead Sponsor:
Université NAZI BONI
Collaborating Sponsors:
Assistance Publique - Hôpitaux de Paris
Conditions:
Acute Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute respiratory failure (ARF) is a frequent medical emergency, involving high costs for health organizations and patients who often require intensive care and respiratory assistance. According to an...
Detailed Description
1. Hypothesis : The use of Boussignac-type CPAP could reduce the need for intubation in patients with acute respiratory failure in a setting where access to invasive ventilation remains very limit...
Eligibility Criteria
Inclusion
- All patients aged 18 years and older will be included in the study if they meet at least one of the following criteria :
- Acute respiratory distress, defined as dyspnea respiratory rate ≥ 25 cycles/min
- Hypoxemia, defined as the need for more 6 liters of oxygen to maintain an oxygen saturation (SpO2) of ≥ 92%. The fraction of inspired oxygen (FiO2) will be estimated using the 3% rule.
Exclusion
- Patients with any of the following criteria will not be included in the study:
- Pregnant or breastfeeding women
- Persons deprived of their liberty
- Exacerbation of asthma, chronic obstructive pulmonary disease, or another chronic respiratory disease
- Moderate to large amount of unilateral or bilateral undrained pleural effusion
- Contraindication to CPAP: patient refusal, undrained pneumothorax, chest injury, repeated or large vomiting, upper gastrointestinal bleeding, craniofacial trauma, severe upper airway obstruction, or tetraplegia in the initial phase
- Cardiac arrest, severe arrhythmias, shock requiring the use of vasopressors (norepinephrine, adrenaline, dopamine)
- Altered level of consciousness (Glasgow Coma Scale score \< 13), repeated seizures, or status epilepticus
- Medical decision to limit treatment: no intubation, no admission to intensive care
- Refusal to participate in the study or participation in another interventional study on respiratory distress or acute respiratory failure.
Key Trial Info
Start Date :
July 9 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 20 2026
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT06912360
Start Date
July 9 2025
End Date
February 20 2026
Last Update
July 28 2025
Active Locations (4)
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1
Centre Hospitalier Universitaire Souro Sanou
Bobo-Dioulasso, Houet, Burkina Faso, 01 BP 676
2
CHU Yalgado Ouedraogo
Ouagadougou, Kadiogo, Burkina Faso, 03 BP 702250311655
3
CHU Tengandogo
Ouagadougou, Kadiogo, Burkina Faso, 03 BP 7067
4
CHU Bogodogo
Ouagadougou, Kadiogo, Burkina Faso, 14 BP 371