Status:
NOT_YET_RECRUITING
Esketamine Combined With PRF for Trigeminal Postherpetic Neuralgia
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
Beijing Xiaotangshan Hospital
The First Hospital of Fangshan District,Beijing
Conditions:
Postherpetic; Neuralgia, Trigeminal (Etiology)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This trial's primary objective is to compare the analgesic efficacy of esketamine in combination with pulsed radiofrequency (PRF) against that of PRF monotherapy in patients with trigeminal postherpet...
Detailed Description
This study aims to determine whether the addition of esketamine to the PRF regimen can relieve pain in TPHN patients. By doing so, the research endeavors to identify a rapid, effective, and safe treat...
Eligibility Criteria
Inclusion
- Ages more than 18 years;
- Pain persisting for over three months following the onset of the herpes zoster skin rash;
- Lesions located in the trigeminal nerve or its branches innervated regions；
- Having an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10= worst possible pain)；
- Planned to perform CT-guided PRF treatment of the gasserian ganglion(GG).
Exclusion
- Obstructive sleep apnoea syndrome;
- Those who receive other more invasive treatments, such as radiofrequency thermocoagulation (RFT) of GG.
- A history of systemic immune diseases, organ transplantation, or cancers;
- A history of severe cardiopulmonary, hepatic, renal dysfunction or coagulation function disorder;
- A history of schizophrenia, epilepsy, or myasthenia gravis, delirium;
- Comorbid hyperthyroidism or phaeochromocytoma;
- Recent history of drug abuse;
- Having contraindications to esketamine;
- Communication difficulties.
- Women who are preparing for pregnancy, in the pregnancy or lactation period.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
174 Patients enrolled
Trial Details
Trial ID
NCT06914180
Start Date
April 1 2025
End Date
July 1 2026
Last Update
April 9 2025
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070