Status:
NOT_YET_RECRUITING
Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A Randomized Clinical Trial
Lead Sponsor:
Universitat Internacional de Catalunya
Conditions:
Peri-implantitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized, placebo-controlled clinical trial evaluates the efficacy of a polynucleotide and hyaluronic acid-based gel (PN-HA) as adjunctive therapy to non-surgical flapless treatment of peri-imp...
Detailed Description
Study design This study will be a randomized controlled, clinical trial with 6 months follow-up. Participants: Subjects eligible for the study will be identified from patients referred to the Clíni...
Eligibility Criteria
Inclusion
- Subjects with (I) ≥ 18 years of age, the presence of at least one implant diagnosed with peri-implantitis, intraosseous ≥ 3mm defects, presence of screw-retained single-unit crowns and partial dental prosthesis that allowed correct access for brushing; and, if not, prostheses that could be modified.
Exclusion
- Subjects will be excluded from the study if they had received previous non-surgical peri-implantitis treatment during the last 6 months or surgical treatment, were pregnant or breast-feeding, had received antibiotic treatment in the previous 3 months, had systemic conditions that contraindicated treatment, smoking more than 10 cigarettes/day or presents a poor plaque control (Plaque Index \< 20%), implant mobility.
Key Trial Info
Start Date :
September 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT06914518
Start Date
September 20 2025
End Date
June 1 2026
Last Update
September 23 2025
Active Locations (2)
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1
Clinica Universitaria ́̀ d'Odontologia - UIC Barcelona at the Periodontology Department
Sant Cugat del Vallès, Barcelona, Spain, 08195
2
08195
Sant Cugat del Vallès, Bracelona, Spain, 08195