Status:
NOT_YET_RECRUITING
PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy
Lead Sponsor:
University of California, Los Angeles
Conditions:
Postpartum Hypertension (PPHT)
Eligibility:
FEMALE
18-64 years
Phase:
PHASE4
Brief Summary
This randomized controlled trial compares two common medications, labetalol and extended-release nifedipine, to determine which is more effective at managing postpartum high blood pressure. We hypothe...
Detailed Description
Hypertensive disorders complicate approximately 10% of pregnancies in the United States and are among the leading causes of maternal morbidity and mortality worldwide. These conditions often emerge or...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age ≥18 years Delivery at study institution at ≥28 weeks gestation Postpartum SBP \> 150 and/or DBP \> 100 OR 2 or more SBP \> 140 and/or DBP \> 90 within a 24-hour period Require initiation of an oral antihypertensive medication during postpartum hospital stay or within 7 days of discharge Treating obstetric team amenable to starting either study medication
- Exclusion criteria:
- Treated with oral antihypertensive medications prior to delivery Known allergies or contraindications to nifedipine or labetalol History of moderate persistent to severe asthma, chronic obstructive pulmonary disease, heart failure, or greater than first-degree atrioventricular heart block Unable to provide written informed consent in English
Exclusion
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2025
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT06915792
Start Date
April 1 2025
End Date
October 31 2025
Last Update
April 8 2025
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