Status:
COMPLETED
Medical and Surgical Treatment of MRONJ (Medication-related Osteonecrosis of the Jaw Bones)
Lead Sponsor:
Akdeniz University
Conditions:
Osteonecrosis Due to Drugs, Jaw
Osteonecrosis of the Jaw, Bisphosphonate Related
Eligibility:
All Genders
18+ years
Brief Summary
MRONJ is an acronym used to describe medication-related osteonecrosis of the jaw bones. It has been reported by the AAOMS that bisphosphonates or denosumab can cause this condition. The management of ...
Detailed Description
This study analyzed 116 MRONJ lesions in 102 patients, divided into medical and surgical treatment groups. Sixty patients in medical treatment group were treated with antibiotherapy following oral hyg...
Eligibility Criteria
Inclusion
- Use of antiresorptive and/or antiangiogenic drugs and consequent development of MRONJ.
- Absence of head and neck radiotherapy.
- Presence of necrotic bone in the maxillofacial region for at least 8 weeks.
Exclusion
- Having undergone head and neck radiotherapy.
- Presence of active radiotherapy and/or chemotherapy.
- Missing information in treatment and follow-up records
Key Trial Info
Start Date :
January 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2023
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT06917846
Start Date
January 1 2018
End Date
January 1 2023
Last Update
April 9 2025
Active Locations (1)
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1
Akdeniz University
Antalya, Turkiye, Turkey (Türkiye), 07070