Status:
NOT_YET_RECRUITING
Comparison of Liver Health in Psoriatic Arthritis Patients Using Anti-TNF or Anti-IL17 Treatments
Lead Sponsor:
Bezmialem Vakif University
Conditions:
Psoriatic Arthritis (PsA)
Liver Fibrosis
Eligibility:
All Genders
18-65 years
Brief Summary
Psoriatic arthritis (PsA) is an inflammatory joint disease that can also affect the liver. Some medications used to treat PsA, such as biological agents (TNF-alpha inhibitors and IL-17 inhibitors), ma...
Detailed Description
This is a retrospective, single-center observational study, conducted in the Physical Medicine and Rehabilitation Clinic, designed to assess the impact of long-term biologic therapy on liver health in...
Eligibility Criteria
Inclusion
- Age 18 to 65 years
- Diagnosed with psoriatic arthritis (PsA) according to standard classification criteria
- Receiving biologic therapy (anti-TNF or anti-IL-17) or MTX monotherapy for ≥2 years
- Able to provide historical data (medical records) on liver ultrasound and laboratory parameters
Exclusion
- History of any other chronic liver disease (e.g., viral hepatitis, autoimmune hepatitis)
- Significant alcohol consumption (\>20 g/day women, \>30 g/day men)
- Concomitant use of other hepatotoxic drugs apart from MTX
- Unwillingness or inability to comply with study assessments
Key Trial Info
Start Date :
April 10 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06918886
Start Date
April 10 2025
End Date
May 1 2025
Last Update
April 9 2025
Active Locations (1)
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1
Bezmialem Vakif University
Istanbul, Fatih, Turkey (Türkiye), 34093