Status:
ACTIVE_NOT_RECRUITING
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis
Lead Sponsor:
Medical University of Bialystok
Conditions:
Periodontal Disease
Periodontitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodon...
Detailed Description
Forty subjects diagnosed with periodontitis were randomly divided into two groups. In the test group, SRP was performed with the subsequent application of iPRF into periodontal pockets, while in the c...
Eligibility Criteria
Inclusion
- clinical and radiological features of periodontitis in stage II, III or IV
- presence of at least 4 teeth and at least 2 pockets (localized not on the same tooth) with a depth of at least 5 mm in each quadrant
Exclusion
- periodontal treatment within 3 months prior to the study;
- antibiotic therapy within 3 months prior to the study;
- smoking; presence of systemic diseases affecting periodontal healing, i.e.: immunosuppressive diseases, diabetes, osteoporosis, AIDS, hypertension treated with calcium channel blockers;
- use of steroids or other immunosuppressive drugs;
- coagulation disorders and use of drugs affecting its mechanisms;
- pregnant and breastfeeding women
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06920849
Start Date
April 1 2022
End Date
June 30 2025
Last Update
April 10 2025
Active Locations (1)
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1
Department of Integrated Dentistry, Medical University of Białystok
Bialystok, Poland, 15-089