Status:
NOT_YET_RECRUITING
Phosphorus-31 Spectroscopy in Phosphate Diabetes
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Phosphate Diabetes
X-linked Hypophosphatemia
Eligibility:
All Genders
10+ years
Phase:
NA
Brief Summary
Phosphate diabetes is defined by urinary phosphate wasting due to impaired tubular reabsorption. It can be classified based on either a genetic or acquired origin. Chronic hypophosphatemia causes rick...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Patients:
- Patient ≥ 10 years old with phosphate diabetes, i.e., genetically confirmed XLH or phosphate diabetes of another origin characterized by hypophosphatemia with a decreased Tm/GFR.
- Patient has given consent to participate in the study.
- Signed consent (by both legal representatives for minor patients).
- Patient regularly followed up within the pediatric nephrology services at the Femme Mère Enfant hospital and the nephrology-functional exploration services at the Edouard Herriot hospital.
- Inclusion Criteria for Pediatric Controls:
- Patient aged 10 to 17 years, without chronic kidney disease, without hypophosphatemia, without muscular abnormalities, and without growth disorders.
- Patient has given consent to participate in the study.
- Signed consent (by both legal representatives for minor patients).
- Patient regularly followed up within the pediatric nephrology services at the Femme Mère Enfant hospital.
- Inclusion Criteria for Adult Controls:
- Patient without chronic kidney disease, without hypophosphatemia, without muscular abnormalities, and without malnutrition.
- Patient has given consent to participate in the study.
- Signed consent.
- Patient regularly followed up within the renal functional exploration services at the Edouard Herriot hospital.
Exclusion
- Pregnant, parturient, or breastfeeding women
- Individuals deprived of liberty by a judicial or administrative decision
- Individuals receiving psychiatric care
- Individuals admitted to a healthcare or social institution for purposes other than research
- Adults under legal protection (guardianship, curators)
- Individuals not affiliated with a social security system or benefiting from a similar scheme
- Subjects participating in another interventional study with an exclusion period still in effect at pre-inclusion
- General contraindications for MRI: wearing a pacemaker/ICD (implantable cardiac device) or mechanical heart valves not MRI-compatible, presence of non-MRI-compatible equipment, presence of metallic objects.
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT06921720
Start Date
May 1 2025
End Date
May 1 2027
Last Update
April 13 2025
Active Locations (2)
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1
Hôpital femme mère enfant, hospices civils de Lyon
Bron, France, 69500
2
Hôpital Edouard Herriot, Hospices Civils de Lyon
Lyon, France, 69003