Status:
COMPLETED
Investigating the Acute Effects of Increasing Glucagon Exposure in Healthy Participants
Lead Sponsor:
Nicolai Jacob Wewer Albrechtsen
Conditions:
Glucose Metabolism
Glucagon
Eligibility:
All Genders
25-70 years
Phase:
NA
Brief Summary
In this study the investigators will investigate the acute effects of increasing glucagon exposure on metabolic parameters in healthy participants. Participants will participate in one study day. Aft...
Detailed Description
Ten participants with normal health will be included, and each participant will participate in one study day. Participants will arrive after an overnight fast and will be placed in a hospital bed in ...
Eligibility Criteria
Inclusion
- Capable of understanding the participant information and signing the consent form
- Between 25 and 70 years of age at the time of screening
- Body mass index (BMI) ≤ 25 kg/m2 at the time of screening
Exclusion
- Enrolment in other research projects that might interfere with the study
- Diabetes diagnosis (type 1 and 2)
- Pregnancy or breastfeeding
- Use of medications which, in the opinion of the investigator, may jeopardise participant's safety or compliance with the protocol
- Impaired liver function defined as either alanine aminotransferase (ALAT) and/or aspartate aminotransferase (ASAT) ≥ 2 times normal values
- Kidney disease defined as serum creatinine levels ≥ 126 μmol/L for male and ≥ 111 μmol/L for female
- Inadequately treated blood pressure at screening defined as repeated resting blood pressure outside the range 90-150 mmHg for systolic and 50-100 mmHg for diastolic
- Active or recent malignant disease
- Current or history of severe alcohol use or drug/chemical abuse as per investigator's judgement
- Any chronic disorders or severe diseases which, in the opinion of the investigator, might jeopardise participant's safety or compliance with the protocol
Key Trial Info
Start Date :
March 31 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 19 2025
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06921824
Start Date
March 31 2025
End Date
September 19 2025
Last Update
December 24 2025
Active Locations (1)
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1
Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Copenhagen, Denmark, 2400