Status:
RECRUITING
Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements
Lead Sponsor:
University of Hamburg-Eppendorf
Conditions:
Intraoperative Bradycardia
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The RAPID trial is a randomized, single-center trial investigating whether giving atropine at heart rates below 60 beats per minute versus giving atropine only at heart rates below 30 beats per minute...
Eligibility Criteria
Inclusion
- Consenting patients ≥50 years scheduled for elective non-cardiac surgery with general anesthesia that is expected to last ≥60 minutes with at least two of the following risk criteria for developing acute kidney injury:
- Age ≥65 years
- American Society of Anesthesiologists physical status III or IV
- Chronic arterial hypertension
- Diabetes mellitus requiring medication
- Intraabdominal surgery
- Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)
Exclusion
- Patients with the following exclusion criteria: contraindication for atropine administration (e.g., myasthenia gravis, high-grade aortic stenosis, high-grade coronary artery disease, glaucoma, paralytic ileus, prostatic hypertrophy); renal replacement therapy within the previous 3 months; chronic kidney disease with an estimated glomerular filtration rate \<20 mL/min/1.73 m2; pregnancy.
Key Trial Info
Start Date :
April 7 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT06922097
Start Date
April 7 2025
End Date
February 1 2026
Last Update
May 20 2025
Active Locations (1)
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1
University Medical Center Hamburg-Eppendorf
Hamburg, Germany, 20246