Status:
NOT_YET_RECRUITING
Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Conditions:
Post Operative Analgesia
Opioid Consumption, Postoperative
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after...
Detailed Description
In 2019, the Institut national d'excellence en santé et services sociaux (INESSS) stated that IV acetaminophen is an acceptable short-term pain treatment option in combination with opioid analgesics f...
Eligibility Criteria
Inclusion
- Age 18 years or older.
- Underwent abdominal surgery
- Underwent elective surgery.
- Hospitalized in the digestive surgery, hepatobiliary and pancreatic surgery, or gynecology and gynecologic oncology units at CHUM.
- Declared NPO immediately post-surgery, meaning they cannot take oral medications.
Exclusion
- Hypersensitivity to acetaminophen or an excipient in the administered formulations
- Hepatic insufficiency with a Child-Turcotte-Pugh score of B or C.
- Weight \< 50 kg (patients requiring a lower acetaminophen dose).
- Active pregnancy or breastfeeding.
- Opioid use disorder (OUD) under active treatment
- Non-opioid-naïve patients: those who received a long-acting opioid within seven days preceding surgery. This criterion will be verified through patient interviews and cross-checked with medical records.
- Use of illicit recreational substances.
- Prior participation in this study.
- Ectopic patients: physically located in a unit other than digestive surgery (11 South), hepatobiliary and pancreatic surgery (14 South), or gynecology and gynecologic oncology (12 South).
Key Trial Info
Start Date :
April 28 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 15 2025
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT06923540
Start Date
April 28 2025
End Date
August 15 2025
Last Update
April 11 2025
Active Locations (1)
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1
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 0A9