Status:
COMPLETED
The Efficacy of Erythropoietin Oral Gel Versus Erythropoietin Mouthwash in the Management of Recurrent Aphthous Stomatitis
Lead Sponsor:
Future University in Egypt
Conditions:
Recurrent Aphthous Stomatitis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Erythropoietin (EPO) exerts anti-inflammatory effects by inhibiting NF- kappa B-dependent formation of pro-inflammatory cytokines, thus it reduces local and circulating levels of these disease (recurr...
Detailed Description
Sixty patients with recurrent aphthous stomatitis were randomly assigned into three equal groups to receive topical Erythropoietin oral gel four times per day (after meals and at bedtime) (Group I). ...
Eligibility Criteria
Inclusion
- All patients should be free from any systemic disease or Behcet syndrome.
- Patients ≥18 years of age, male or female are eligible.
- Oral pain score of 4 or higher on a scale of 0-10 with 0 representing no pain in the presence of oral ulceration.
- Patient has only aphthous ulcer and It should had not been passed more than 4 days from beginning of their ulcer.
Exclusion
- • Patients with poor oral hygiene or not willing to perform oral hygiene measures.
- Smoking and alcohol use.
- Pregnant and lactating females
- Patients with history of any topical or systemic medication or steroid therapy 1 month prior to the investigation.
- The vulnerable group; prisoners, mentally or physically disabled patients.
Key Trial Info
Start Date :
July 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 27 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06923605
Start Date
July 1 2024
End Date
February 27 2025
Last Update
August 26 2025
Active Locations (1)
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1
Future university in Egypt
New Cairo, Cairo Governorate, Egypt, 4710001