Status:
RECRUITING
Cancer of the Lung And SeneScencE - Prospective Cohort 1
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
ARC Foundation and Inserm
URC-CIC Paris Descartes Necker Cochin
Conditions:
Non-Small Cell Lung Cancer
Eligibility:
All Genders
70+ years
Phase:
NA
Brief Summary
The main objective is to identify and assess the predictive value of ageing and senescence biomarkers (methylome, telomeres, inflammageing) and senescent cells in tissues to improve prognosis assessme...
Detailed Description
Geriatric assessment allows oncologists to stratify older cancer patients into risk categories (fit, vulnerable and frail) but few patients benefit from it. Yet, they do not evaluate physiological res...
Eligibility Criteria
Inclusion
- Patients 70 years and over
- Local or locally advanced (Clinic stage I-IIIA) NSCLC (clinically (or radiologically) suspected or histologically proven)
- Surgical Curative Intent
- Signed informed Consent (or signed by the curator or tutorship)
- Affiliated to social security administrative care service
Exclusion
- Synchronous cancer (histologically proven or strongly suspected non-lung cancer in the 6 months prior to inclusion (excluding basal cell cancer and prostate cancer with local treatment (radiotherapy or surgery) or active surveillance without systemic treatment (chemotherapy, hormone therapy)).
- Subject deprived of liberty by judicial or administrative decision or patient under guardianship
- Subject unable to understand the purpose and conditions of the study and unable to give consent
Key Trial Info
Start Date :
July 9 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2032
Estimated Enrollment :
385 Patients enrolled
Trial Details
Trial ID
NCT06923618
Start Date
July 9 2025
End Date
July 1 2032
Last Update
December 15 2025
Active Locations (1)
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1
Henri Mondor Hospital
Créteil, Île-de-France Region, France, 94000