Status:
ENROLLING_BY_INVITATION
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
Lead Sponsor:
Feng Gao
Conditions:
Acute Basilar Artery Occlusion
Posterior Circulation Large Infarct
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute b...
Detailed Description
This study is a multicenter, prospective, cohort study that prospectively enrolled consecutive patients with acute basilar artery occlusion and large core infarction in the posterior circulation, conf...
Eligibility Criteria
Inclusion
- Age 18-80 years old;
- Acute ischemic stroke in the posterior circulation, the onset of stroke (or last well known) to the enrollment time within 24 hours;
- CTA/MRA/DSA confirmed acute basilar artery occlusion;
- Posterior circulation large infarct: NCCT or DWI showed pc-ASPECTS ≤ 5 points, or pontine midbrain index (PMI) ≥ 3 points;
- NIHSS score ≥10 points after the onset of the stroke and before enrollment;
- Able to live independently before the onset of the disease (mRS score ≤2 points);
- The subject or legal representative is able to sign the informed consent form.
Exclusion
- Intracranial hemorrhage (except microhemorrhage) on CT/MRI ;
- CT/MRI revealed large infarction in the cerebellar hemisphere, with significant mass effect causing compression of the fourth ventricle or brainstem;
- CT or MRI showed bilateral complete thalamic infarction;
- Occlusion of anterior and posterior circulation arteries confirmed by CTA/MRA/DSA;
- The presence of intracranial tumors (except for small meningiomas and cerebral aneurysms with a diameter of \<3mm);
- Patients with known or highly suspected chronic basilar artery occlusion.;
- Known severe allergy to contrast agents (except for mild rash);
- Refractory hypertension (defined as systolic blood pressure \> 185 mmHg or diastolic blood pressure \>110 mmHg) that cannot be controlled by drug therapy;
- Known pregnant or lactating females, or positive pregnancy test before enrollment;
- Acute cerebral infarction within 48 hours after cardiovascular and cerebrovascular intervention or major surgery (patients more than 48 hours can be enrolled).
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06924996
Start Date
January 1 2023
End Date
December 31 2025
Last Update
April 13 2025
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070