Status:
ACTIVE_NOT_RECRUITING
Application of in Vivo Splitting Technique in Adult Liver Transplantation
Lead Sponsor:
Ningbo Medical Center Lihuili Hospital
Conditions:
Liver Transplantation
Eligibility:
All Genders
16-75 years
Brief Summary
The feasibility of split liver transplantation (SLT) remains controversial. This study aimed to evaluate the outcomes of SLT in adult recipients and to identify specific areas of improvements. A retro...
Eligibility Criteria
Inclusion
- For the donor graft:
- age of 18-60 years;
- BMI of 19-28 kg/m2;
- hemodynamic stability or use of a single vasoactive drug with a small dosage (norepinephrine ≤ 0.1 μg/kg/min or dopamine ≤ 5 μg/kg/min);
- liver steatosis ≤ 10%;
- liver functional indicators (ALT, AST, total bilirubin quantification) ≤ 3 times the normal value;
- blood sodium ≤ 160 mmol/L;
- For the SLT recipients
- Patients who had registered in the China Organ Transplant Response Systems.
- Initial liver transplantation.
- Graft-to-Recipient Weight Ratio (GRWR) ≥ 1%.
Exclusion
- For the donor graft
- uncontrollable infection
- significant vascular and biliary variation.
- For the recipients
- Severe portal hypertension.
- Significant vascular variation.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06925828
Start Date
January 1 2021
End Date
December 31 2025
Last Update
April 13 2025
Active Locations (1)
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1
Ningbo Medical Centre Lihuili Hospital
Ningbo, Zhejiang, China, 315000