Status:
NOT_YET_RECRUITING
Research on the Safety and Efficacy of Intraoperative Radiation Therapy in Malignant Cerebral Tumor
Lead Sponsor:
First Affiliated Hospital, Sun Yat-Sen University
Conditions:
Glioblastoma
Brain Tumor, Primary
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
According to the latest national cancer statistics released by the National Cancer Center in February 2022, intracranial tumors account for about 60%-70% of the more than 3.5 million cancer patients, ...
Eligibility Criteria
Inclusion
- 18-75 years old, non-pregnant or lactating women
- KPS ≥60
- MRI and CT of the brain with contrast should be considered for diagnosis of high-grade glioma or other malignant brain tumors
- No other underlying diseases that affect survival time, follow-up or quality of life, and no other serious organic lesions
- Not receive radiotherapy, chemotherapy and other treatment methods for intracranial lesions in the past;
- Tumor located supratentorium, and the position should ensure that the tumor resection volume is more than 90%;
- The required dose of standard radiotherapy exceeds normal tissue tolerance
- No related contraindications such as intraoperative radiotherapy and craniotomy.
Exclusion
- Refuse to undergo craniotomy or radiation therapy;
- The postoperative paraffin pathological results were not high-grade gliomas or other cranial malignant tumors;
- Refuse to participate in the clinical trial after informed consent without the above exclusion criteria.
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2030
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06929819
Start Date
June 1 2025
End Date
May 31 2030
Last Update
April 16 2025
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