Status:
RECRUITING
Effectiveness of Midodrine as an Adjuvant to Norepinephrine in Weaning Critically Ill Patients From Vasopressors
Lead Sponsor:
Sohag University
Conditions:
Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to evaluate the effectiveness of midodrine as an adjuvant to norepinephrine in weaning critically ill patients from vasopressors
Eligibility Criteria
Inclusion
- Patients with refractory hypotension on an intravenous vasopressor for more than 24 h but deemed clinically stable.
- Patients on noradrenaline support \<10 μg/min
Exclusion
- Known allergy to midodrine.
- Severe shock state, as evidenced by multiple vasopressor infusions or high vasopressor requirement (i.e. noradrenaline \>10 μg/min)
- Patients with severe organic heart disease (e.g., heart failure, sever aortic stenosis), pregnancy, thyrotoxicosis or pheochromocytoma.
- Those with no enteral route available.
Key Trial Info
Start Date :
March 13 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 13 2025
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT06930235
Start Date
March 13 2025
End Date
October 13 2025
Last Update
April 16 2025
Active Locations (1)
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1
Sohag University Hospital
Sohag, Egypt