Status:
NOT_YET_RECRUITING
Dexamethasone for Ureteral STent Symptoms (DUSTS)
Lead Sponsor:
The Methodist Hospital Research Institute
Conditions:
Ureteral Stent-Related Symptom
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The ...
Detailed Description
Patient will be in the study for a duration of 30 days. Randomization will be performed on the day of surgery using the NIH Clinical Trial Randomization Tool. In the preoperative area, a finger stick...
Eligibility Criteria
Inclusion
- Age 18-70 years old
- Patients who are undergoing unilateral retrograde ureteroscopy (semi-rigid or flexible) with planned ureteral stent placement for treatment of renal/ureteral stones
- Patients who can read and understand English
- Patients who can follow up post-operatively within 7 days at Houston Methodist Hospital
Exclusion
- Untreated UTI
- HbA1c ≥6.5 on preoperative testing
- Patients with prior diagnosis of any type of diabetes mellitus
- Patients with immunosuppression, including chronic corticosteroid use
- Patients with bleeding disorder
- Patients with chronic liver disease, cirrhosis, and liver failure.
- Patients taking strong CYP3A4 inducers or inhibitors within two weeks of screening
- Chronic opioid analgesic use
- Congenital renal abnormalities (e.g. pelvic kidney, ureteric duplication) that may impair stent placement
- Concurrent genitourinary malignancy
- Urinary diversion
- Renal transplantation
- History of interstitial cystitis/painful bladder syndrome, prostatitis, pelvic pain due to other conditions (e.g. endometriosis)
- Neurologic disorder (e.g. spinal cord injury, multiple sclerosis, spina bifida)
- Pregnant or breastfeeding
- Patients with cognitive impairments or untreated psychiatric illness
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06930690
Start Date
May 1 2025
End Date
January 1 2026
Last Update
April 16 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Houston Methodist Hospital
Houston, Texas, United States, 77005